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A randomized, controlled, open label non-inferiority trial of intravenous ferric carboxymaltose versus

Frontiers of Medicine doi: 10.1007/s11684-023-1001-2

Abstract: This open label, randomized, controlled, non-inferiority trial was conducted at multiple sites in ChinaAmong the 371 randomized subjects, a similar percentage of subjects treated with FCM and IS achieved

Keywords： iron deficiency     anemia     intravenous iron     ferric carboxymaltose     iron sucrose     Hb response     early response    

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based on traditional Chinese medicine patterns on patients with pneumoconiosis: a pilot double-blind, randomized, and placebo-controlled study

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 736-744 doi: 10.1007/s11684-021-0870-5

Abstract: A double-blind, randomized, and placebo-controlled trial was conducted for 24 weeks, in which 96 patients

Keywords： pneumoconiosis     randomized controlled trials     traditional Chinese medicine    

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older patients with chronic obstructive pulmonary disease: a subgroup analysis from a four-center, randomized, controlled study

Minghang Wang,Jiansheng Li,Suyun Li,Yang Xie

Frontiers of Medicine 2014, Volume 8, Issue 3,   Pages 368-375 doi: 10.1007/s11684-014-0360-0

Abstract: older patients with chronic obstructive pulmonary disease (COPD) through a four-center, open-label, randomizedcontrolled trial.Patients were divided into the trial group treated using conventional western medicine and Bu-Fei Jian-PiA total of 136 patients≥65 years completed the study, with 63 patients comprising the trial groupNo differences were observed between the trial and control groups with regard to FVC, FEV1, and FEV1%

Keywords： chronic obstructive pulmonary disease     older adult     clinical trial     Bu-Fei Jian-Pi granules     Bu-Fei Yi-Shen    

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Low-carbohydrate diets lead to greater weight loss and better glucose homeostasis than exercise: a randomizedclinical trial

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 460-471 doi: 10.1007/s11684-021-0861-6

Abstract: Lifestyle interventions, including dietary adjustments and exercise, are important for obesity management. This study enrolled adults with overweight or obesity to explore whether either low-carbohydrate diet (LCD) or exercise is more effective in metabolism improvement. Forty-five eligible subjects were randomly divided into an LCD group (n=22) and an exercise group (EX, n=23). The subjects either adopted LCD (carbohydrate intake<50 g/day) or performed moderate-to-vigorous exercise (≥30 min/day) for 3 weeks. After the interventions, LCD led to a larger weight loss than EX (−3.56±0.37 kg vs. −1.24±0.39 kg, P<0.001), as well as a larger reduction in fat mass (−2.10±0.18 kg vs. −1.25±0.24 kg, P=0.007) and waist circumference (−5.25±0.52 cm vs. −3.45±0.38 cm, P=0.008). Both interventions reduced visceral and subcutaneous fat and improved liver steatosis and insulin resistance. Triglycerides decreased in both two groups, whereas low-density lipoprotein cholesterol increased in the LCD group but decreased in the EX group. Various glycemic parameters, including serum glycated albumin, mean sensor glucose, coefficient of variability (CV), and largest amplitude of glycemic excursions, substantially declined in the LCD group. Only CV slightly decreased after exercise. This pilot study suggested that the effects of LCD and exercise are similar in alleviating liver steatosis and insulin resistance. Compared with exercise, LCD might be more efficient for weight loss and glucose homeostasis in people with obesity.

Keywords： low-carbohydrate diet     obesity     nonalcoholic fatty liver disease     continuous glucose monitoring     mean sensor glucose    

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Efficacy and safety of benralizumab in patients with eosinophilic asthma: a meta-analysis of randomizedplacebo-controlled trials

Ting Liu, Faping Wang, Geng Wang, Hui Mao

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 340-349 doi: 10.1007/s11684-017-0565-0

Abstract: All randomized controlled trials involving benralizumab treatment for patients with eosinophilic asthmaRandomized-effect models were used in the meta-analysis to calculate the pooled mean difference, relative

Keywords： benralizumab     anti-interleukin-5     monoclonal antibody     eosinophilic asthma     meta-analysis    

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versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage cervical cancer: a randomized, non-inferiority, multicenter trial

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 93-104 doi: 10.1007/s11684-021-0892-z

Abstract: This randomized trial involved nine centers across China.Eligible patients were randomized to receive adjuvant chemotherapy or CCRT after surgery.

Keywords： chemotherapy     cervical cancer     lymph node metastasis     concurrent chemoradiotherapy     quality of life    

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Non-closure of the peritoneum and subcutaneous tissue at radical hysterectomy: A randomized controlledtrial

Zhou-Fang XIONG MD, Wei-Hong DONG MD, Ze-Hua WANG MD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 112-116 doi: 10.1007/s11684-010-0016-7

Abstract: We conducted a trial to assess the influence of closure or nonclosure of the peritoneum and subcutaneousThis randomized controlled trial was performed on 158 cervical cancer patients in our hospital between

Keywords： cervical cancer     radical surgery     peritoneum     subcutaneous tissue    

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versus multi-course methotrexate for low-risk gestational trophoblastic neoplasia: a multi-centric randomizedclinical trial

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 276-284 doi: 10.1007/s11684-021-0855-4

Abstract: In this trial (NCT01823315), 276 patients were analyzed.

Keywords： gestational trophoblastic neoplasia (GTN)     methotrexate (MTX)     dactinomycin (ACTD)    

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Effects of exercise therapy on bone mineral density in early postmenopausal women: a controlled trial

Shilin DENG MD ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 323-329 doi: 10.1007/s11684-009-0061-2

Abstract: The purpose of this article is to determine the effect of a well-designed combined aerobic, resistance, and extension exercise program on bone mineral density (BMD) in postmenopausal women. The population comprised 45 postmenopausal women, who exercised over 12months (exercise group), and 36 women who served as a non-training control group. BMD of the hip, and lumbar spine was measured at the baseline and 12th month. Repeated measurement analysis of variance and nonparametric test were utilized to compare differences between the exercise group and controls. Thirty-six out of 45 persons in the exercise group and 36 controls completed the study. Average compliance was 82.2% for the whole exercise group at the 12th month. All the subjects had decreased BMD, but the rate of bone loss was lower in the exercise group than in the control group at the L4 and hip. Although the exercise program in this study may probably reduce the rate of bone loss in weight-bearing skeletal sites, we do not suggest the exercise by itself be viewed as prevention or treatment for osteoporosis. Further, the exact dose-response relationship of exercise and bone mass in early postmenopause is not clear.

Keywords： early postmenopausal women     bone mineral density     exercise     effects    

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Effects of Shuanghuanglian oral liquids on patients with COVID-19: a randomized, open-label, parallel-controlled, multicenter clinical trial

Li Ni, Zheng Wen, Xiaowen Hu, Wei Tang, Haisheng Wang, Ling Zhou, Lujin Wu, Hong Wang, Chang Xu, Xizhen Xu, Zhichao Xiao, Zongzhe Li, Chenze Li, Yujian Liu, Jialin Duan, Chen Chen, Dan Li, Runhua Zhang, Jinliang Li, Yongxiang Yi, Wei Huang, Yanyan Chen, Jianping Zhao, Jianping Zuo, Jianping Weng, Hualiang Jiang, Dao Wen Wang

Frontiers of Medicine 2021, Volume 15, Issue 5,   Pages 704-717 doi: 10.1007/s11684-021-0853-6

Abstract: We conducted a randomized, open-label, parallel-controlled, multicenter trial on the use of Shuanghuanglian

Keywords： COVID-19     SARS-CoV-2     Shuanghuanglian oral liquid     clinical trial    

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plantarum CCFM8610 Alleviates Irritable Bowel Syndrome and Prevents Gut Microbiota Dysbiosis: A Randomized, Double-blind, Placebo-controlled, Pilot Clinical Trial Article

Yang Liu, Xinjie Yu, Leilei Yu, Fengwei Tian, Jianxin Zhao, Hao Zhang, Long Qian, Qun Wang, Zhengqing Xue, Qixiao Zhai, Wei Chen

Engineering 2021, Volume 7, Issue 3,   Pages 376-385 doi: 10.1016/j.eng.2020.06.026

Abstract: The study was a 12-week, randomized, double-blind, placebo-controlled, pilot clinical trial.

Keywords： Lactobacillus plantarum     Irritable bowel syndrome     Gut microbiota     Butyric acid     Clinical trial    

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CCFM1077 Attenuates Hyperlipidemia by Modulating the Gut Microbiota Composition and Fecal Metabolites: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Article

Chuanqi Chu, Jinchi Jiang, Leilei Yu, Yiwen Li, Songli Zhang, Wei Zhou, Qun Wang, Jianxin Zhao, Qixiao Zhai, Fengwei Tian, Wei Chen

Engineering 2023, Volume 28, Issue 9,   Pages 193-205 doi: 10.1016/j.eng.2023.04.010

Abstract: This study was a six-week, randomized, double-blind, and placebo-controlled pilot clinical trial.

Keywords： Probiotics     Bifidobacterium longum     Hyperlipidemia     Gut microbiota     Fecal metabolites     Bile acid (BA)    

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Tocilizumab in patients with moderate or severe COVID-19: a randomized, controlled, open-label, multicentertrial

Dongsheng Wang, Binqing Fu, Zhen Peng, Dongliang Yang, Mingfeng Han, Min Li, Yun Yang, Tianjun Yang, Liangye Sun, Wei Li, Wei Shi, Xin Yao, Yan Ma, Fei Xu, Xiaojing Wang, Jun Chen, Daqing Xia, Yubei Sun, Lin Dong, Jumei Wang, Xiaoyu Zhu, Min Zhang, Yonggang Zhou, Aijun Pan, Xiaowen Hu, Xiaodong Mei, Haiming Wei, Xiaoling Xu

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 486-494 doi: 10.1007/s11684-020-0824-3

Abstract: We conducted a randomized, controlled, open-label multicenter trial among COVID-19 patients.Thirty-three patients were randomized to the tocilizumab group, and 32 patients to the control group.

Keywords： tocilizumab     coronavirus disease 2019 (COVID-19)     cytokine storm    

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Efficacy and Safety of Triazavirin Therapy for Coronavirus Disease 2019: A Pilot Randomized ControlledTrial Article

Xiaoke Wu, Kaijiang Yu, Yongchen Wang, Wanhai Xu, Hongli Ma, Yan Hou, Yue Li, Benzhi Cai, Liying Zhu, Min Zhang, Xiaoli Hu, Jingshu Gao, Yu Wang, Huichao Qin, Wenjie Wang, Mingyan Zhao, Xia Wu, Yong Zhang, Lu Li, Kang Li, Zhimin Du, Ben Willem J. Mol, Baofeng Yang

Engineering 2020, Volume 6, Issue 10,   Pages 1185-1191 doi: 10.1016/j.eng.2020.08.011

Abstract: To assess the efficacy and safety of Triazavirin therapy for COVID-19, we conducted a randomized, double-blindedcontrolled trial involving hospitalized adult patients with COVID-19.Participants were enrolled from ten sites, and were randomized into two arms of the study with a ratioWe randomized 52 patients for treatment with Triazavirin (n = 26) or a placebo (n = 26)

Keywords： Coronavirus disease 2019     Triazavirin     Efficacy     Safety    

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Title Author Date Type Operation

A randomized, controlled, open label non-inferiority trial of intravenous ferric carboxymaltose versus

Journal Article

based on traditional Chinese medicine patterns on patients with pneumoconiosis: a pilot double-blind, randomized, and placebo-controlled study

Journal Article

older patients with chronic obstructive pulmonary disease: a subgroup analysis from a four-center, randomized, controlled study

Minghang Wang,Jiansheng Li,Suyun Li,Yang Xie

Journal Article

Low-carbohydrate diets lead to greater weight loss and better glucose homeostasis than exercise: a randomizedclinical trial

Journal Article

Lingguizhugan Decoction, a Chinese herbal formula, improves insulin resistance in overweight/obese subjects with non-alcoholic fatty liver disease: a translational approach

Journal Article

Efficacy and safety of benralizumab in patients with eosinophilic asthma: a meta-analysis of randomizedplacebo-controlled trials

Ting Liu, Faping Wang, Geng Wang, Hui Mao

Journal Article

versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage cervical cancer: a randomized, non-inferiority, multicenter trial

Journal Article

Non-closure of the peritoneum and subcutaneous tissue at radical hysterectomy: A randomized controlledtrial

Zhou-Fang XIONG MD, Wei-Hong DONG MD, Ze-Hua WANG MD,

Journal Article

versus multi-course methotrexate for low-risk gestational trophoblastic neoplasia: a multi-centric randomizedclinical trial

Journal Article

Effects of exercise therapy on bone mineral density in early postmenopausal women: a controlled trial

Shilin DENG MD ,

Journal Article

Effects of Shuanghuanglian oral liquids on patients with COVID-19: a randomized, open-label, parallel-controlled, multicenter clinical trial

Li Ni, Zheng Wen, Xiaowen Hu, Wei Tang, Haisheng Wang, Ling Zhou, Lujin Wu, Hong Wang, Chang Xu, Xizhen Xu, Zhichao Xiao, Zongzhe Li, Chenze Li, Yujian Liu, Jialin Duan, Chen Chen, Dan Li, Runhua Zhang, Jinliang Li, Yongxiang Yi, Wei Huang, Yanyan Chen, Jianping Zhao, Jianping Zuo, Jianping Weng, Hualiang Jiang, Dao Wen Wang

Journal Article

plantarum CCFM8610 Alleviates Irritable Bowel Syndrome and Prevents Gut Microbiota Dysbiosis: A Randomized, Double-blind, Placebo-controlled, Pilot Clinical Trial

Yang Liu, Xinjie Yu, Leilei Yu, Fengwei Tian, Jianxin Zhao, Hao Zhang, Long Qian, Qun Wang, Zhengqing Xue, Qixiao Zhai, Wei Chen

Journal Article

CCFM1077 Attenuates Hyperlipidemia by Modulating the Gut Microbiota Composition and Fecal Metabolites: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Chuanqi Chu, Jinchi Jiang, Leilei Yu, Yiwen Li, Songli Zhang, Wei Zhou, Qun Wang, Jianxin Zhao, Qixiao Zhai, Fengwei Tian, Wei Chen

Journal Article

Tocilizumab in patients with moderate or severe COVID-19: a randomized, controlled, open-label, multicentertrial

Dongsheng Wang, Binqing Fu, Zhen Peng, Dongliang Yang, Mingfeng Han, Min Li, Yun Yang, Tianjun Yang, Liangye Sun, Wei Li, Wei Shi, Xin Yao, Yan Ma, Fei Xu, Xiaojing Wang, Jun Chen, Daqing Xia, Yubei Sun, Lin Dong, Jumei Wang, Xiaoyu Zhu, Min Zhang, Yonggang Zhou, Aijun Pan, Xiaowen Hu, Xiaodong Mei, Haiming Wei, Xiaoling Xu

Journal Article

Efficacy and Safety of Triazavirin Therapy for Coronavirus Disease 2019: A Pilot Randomized ControlledTrial

Xiaoke Wu, Kaijiang Yu, Yongchen Wang, Wanhai Xu, Hongli Ma, Yan Hou, Yue Li, Benzhi Cai, Liying Zhu, Min Zhang, Xiaoli Hu, Jingshu Gao, Yu Wang, Huichao Qin, Wenjie Wang, Mingyan Zhao, Xia Wu, Yong Zhang, Lu Li, Kang Li, Zhimin Du, Ben Willem J. Mol, Baofeng Yang

Journal Article